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Tirzepatide has been shown to lower body weight and fat mass by decreasing food intake through appetite regulation and modulation of fat utilisation, with an associated improvement in health-related quality of life [17,18,19]
Poor kidney function could create additional burden rather than benefit
Rather than full 4 mg or full 8 mg doses, some healthcare providers prescribe intermediate amounts
For drugs approaching IRA eligibility, apply the published MFP discount ranges from first-tranche negotiations as a base case, with sensitivity analysis on the contagion effect across the commercial market
doi:10.1001/jamanetworkopen.2022.31982 Bray GA, Ryan DH
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