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The indirect interaction of ZO proteins with the cytoskeleton involves several actin-binding proteins including cortactin (Katsube et al., 1998), alpha-catenin (Muller et al., 2005), protein 4.1R (Mattagajasingh et al., 2000), the Ras target, AF6/afadin, as well as the actin- and myosin-binding proteins, cingulin (D'Atri et al., 2002) and Shroom (Etournay et al., 2007)
Treatments are delivered by licensed nurses under medical direction using pharmaceutical-grade formulations
A simple rotation system works
Commonly reported side effects are minimal and might include mild irritation or redness at the injection site
Csepanyi E, Czompa A, Haines D, Lekli I, Bakondi E, Balla G, et al
Petrov AM, Kasimov MR, Zefirov AL
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