The GLP-1 receptor is a class B G protein-coupled receptor (GPCR) found in: Pancreatic beta cells Hypothalamic and brainstem nuclei Gastrointestinal tract Heart, kidney, and elsewhere Upon activation, it triggers multiple intracellular pathways: cAMP/PKA: enhances insulin secretion PI3K/Akt: promotes cell survival and beta cell function MAPK/ERK: involved in cell proliferation, differentiation, and potentially neuroprotective effects These pathways interact in complex ways depending on cell type, receptor density, and ligand properties
Recently, several retrospective studies of patients with T2D and CKD found that although use of GLP1-RA was associated with improved overall survival compared to use of DPP4i, there was no significant difference in cardiovascular outcomes 42,43
It also contains Riboflavin, Thiamine, Dexpanthenol, Pyridoxine, Methylcobalamin, Niacinamide, and Carnitine
The most powerful results come when both are used in synergy
People say they use beetroot juice, nitrates in the water bottle, bicarbonate of soda before the race and theres this protein gene it costs 100 a shot and apparently it gives you a 10% boost
Photo Credit: Jessica Kielman, Baldwin Publishing 30 mins This lighter version of a classic favorite keeps things flavorful while using leaner protein