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This presented a unique opportunity to cut the estimating effort in half because the company was required to disclose gross rebates received for the past three years
It was preventive cardiology
Article | July 24, 2025 Trimming time: metabolomics insights to speed development of GLP-1 therapies Multiple GLP-1-based therapies for type 2 diabetes and obesity have been approved in recent years, reflecting their strong clinical effectiveness in improving glycemic control
The STEP 5 trial, which focused on semaglutide, found that participants achieved an average weight loss of 15.2% over 104 weeks
Moreover, in humans with obesity, SCFAs are significantly increased in feces [8] while in genetically obese mice there was an increased capacity to extract SCFAs from the diet providing additional energy to the host (about 10% of total energy from the diet) as compared to lean littermates [9]
The reduced appetite from GLP-1 therapy makes it easier to adhere to these dietary patterns, but intentional meal planning ensures adequate nutrition
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