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Such high GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77
Substances that increase GSH levels are being employed with increasing regularity and success in toxicology
This high metabolic demand renders ocular tissues particularly vulnerable to metabolic dysregulation, which can precipitate an energy crisis leading to retinopathy, AMD, and other pathologies
In addition, oral glutathione supplements have been linked to digestive distress, including abdominal cramps or bloating
10.1186/s12905-022-01630-3 BMC Womens Health
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