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These findings highlight the potential of NFX-NS as the first NCs-based formulation of NFX, offering a promising therapeutic alternative for pediatric use and addressing the solubility-related challenges associated with the drug

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Authors contributions Conceptualization, methodology, writing - original draft: Rodrguez-Gonzlez IC Conceptualization, project administration, writing - original draft: Botello-Villagrana F Investigation, writing - review and editing: Gomez-Villalobos SR, Gonzlez-Cant A, Gonzlez-Gonzlez M Investigation, visualization, writing - original draft: Torres-Mancilla XM, Robles E Methodology, visualization, writing - original draft: Luna-Range FA, Gonzalez-Bedolla B Conceptualization, supervision, writing - review and editing: Martinez-Ramirez D All authors of this manuscript meet the authorship criteria established by the International Committee of Medical Journal Editors (ICMJE)

Eligibility and medication decisions are made by external licensed clinicians after intake review