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Effects of charge on antibody tissue distribution and pharmacokinetics
A phase I clinical trial of the anti-CD28 Ab TGN1412 exemplifies this, as the Ab induced cytokine storms in treated individuals, causing severe damage to the lungs and kidneys, and an immediate need of transfer to the intensive care unit [365]
It still represents meaningful, life-improving change for millions of people
Phase 3 results sometimes regress toward more conservative figures
After these initial visits, patients return to the office every four months
These typically occur 3090 minutes after injection
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