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Lineage-specific silencing of PSAT1 induces serine auxotrophy and sensitivity to dietary serine starvation in luminal breast tumors
The translational attractiveness of this strategy lies in its action at a proximal checkpoint upstream of several inflammatory sensing pathways, although this advantage is tempered by a relatively narrow safety window, because higher concentrations of VBIT-4 can suppress mitochondrial respiration, perturb membrane potential and reduce cell viability (169)
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LinCHChenCCChiangHLLiouJMChangCMLuTPet al
Although kidney replacement therapy is the standard method for controlling elevated plasma oxalate concentrations in patients with kidney failure requiring dialysis, more research is needed to define effective elimination strategies at earlier stages of kidney disease
The most common ones among real-world patients seem to be headaches, nausea, dizziness, and injection site redness or irritation that should subside with use
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