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Results at 36 weeks by dose group: The critical finding: the proportion of lean mass loss to total weight loss was comparable to other obesity medications
No published trial has demonstrated that retatrutide's glucagon arm meaningfully preserves lean mass compared with GLP-1/GIP agents, and none has shown it builds muscle
Journal of Alternative Complementary Medicine
Risks and Research Challenges While the benefits are promising, combination protocols come with their own set of challenges
Med 89 , 457464 (2022)
Feb 8, 2026 Two medications
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