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The sarcoplasmic reticulum Ca+ channel RyR2 undergoes SSG under oxidative stress, which initially protects against calcium overload in ischemia-reperfusion injury, whereas it becomes maladaptive in sustained oxidative environments (e.g., catecholamine-induced arrhythmias) (80)
Alpha-lipoic acid attenuates cerebral ischemia and reperfusion injury via insulin receptor and PI3K/Akt-dependent inhibition of NADPH oxidase
Most events were transient and occurred during dose escalation
To further validate the involvement of the PI3K/Akt pathway in the antioxidant effects of HT, we employed the PI3K/Akt pathway inhibitor LY294002 (Fig
Glutathione is composed of three amino acids: cysteine, glycine, and glutamate
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