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It powers liver detox pathways, converting toxins into water-soluble compounds that can be eliminated through urine or bile
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These drugs block the SGLT-2 protein in the proximal convoluted tubule, thereby inducing a glucose-mediated osmotic diuresis and natriuresis, improving several metabolic measures [58]
A diferencia de los GLP1-RA, se ha observado en la evidencia clnica que los IDPP-4 no tienen beneficios cardiovasculares en pacientes con DM2 a pesar de contribuir en el control glucmico, por lo que no cumplen con los nuevos lineamientos en el tratamiento de la DM2, donde se busca reducir la incidencia de complicaciones ms all del control glucmico 58
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