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JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number
Heo, Y.-A
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308 , E1116E1122 (2015)
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