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Diagnosis and Treatment of Parkinson Disease: A Review
The clinical trials included in the review had a high degree of heterogeneity in terms of substance types, patients' characteristics, and types and doses of the administered GLP-1 receptor agonists
Neelakantan and colleagues (Biochem Pharmacol, 2018) reported that 1-methylquinolinium and 1-methylnicotinamide showed no measurable passive diffusion in their assays, whereas 5-amino-1MQ crossed by both passive and active routes with no detectable efflux in Caco-2 cells, and lowered intracellular 1-methylnicotinamide in differentiated 3T3-L1 adipocytes with an EC near 2.3 M
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