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The second, more sustained phase occurs when nutrients directly contact L-cells in the lower small intestine and colon, producing a more prolonged GLP-1 release that continues for several hours after a meal
This captures cases where side effects were severe enough to warrant stopping treatment entirely
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Given the amount of evidence suggesting that DDI can reduce tamoxifen efficacy, even the most skeptical observer would have to admit that there is a non-trivial chance that the interactions are clinically important in some patients
doi: 10.1111/dom.12932, 9 BoothM
Sleep apnea and cardiovascular disease: an American Heart Association/american College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council On Cardiovascular Nursing
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