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Example-4: Alternative Solid phase peptide synthesis of Gln(Trt)-Ala-Ala-Lys(C18diacid mono-t-butyl-y-Glu(AEEA-AEEA)-OtBu)-Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)-Leu-Val- Arg(pbf)-Gly-Arg (pbf)-Gly-OtBu (fragment-6) Stage-1: Preparation of Fmoc-Gln(Trt)-Ala-Ala-Lys(C18diacid mono-t-butyl-y-Glu (AEEA -AEEA)-OtBu)-OH Step-A: CTC resin (50 grams) was taken in a SPPS reactor and dichloromethane was added and allowed it to swell for 10 minutes

Any change in the COMT gene may cause the body to be slower to deactivate and expel these chemicals, which can lead to changes in stress reactions

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