The 2026 KFF Employer Health Benefits Survey reports that roughly 44% of large-employer plans explicitly exclude GLP-1s for weight management, though most cover them for type 2 diabetes and, increasingly, for the SELECT-based cardiovascular indication in adults with established CVD
STEP 1 (published in NEJM 2021) demonstrated that participants receiving semaglutide 2.4 mg experienced mean reductions in total cholesterol of approximately 5-7%, LDL-C reductions of 5-8%, and triglyceride reductions of 12-15% from baseline
Nolen-Doerr says many of his patients are taking GLP-1s to make considerable, tangible impacts on their health and those who stick with the medications can see dramatic results
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The randomized, controlled study recruited over 17,000 people with overweight or obesity and preexisting cardiovascular disease