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Protocol cycling decisions, including continuous vs paused, are determined at the consultation based on IGF-1 response and treatment goals
Additionally, individuals with Type 1 diabetes, those who are pregnant or breastfeeding, and anyone with a serious allergy to any part of Wegovy should not use this medication (Wharton et al., 2025)
Additionally, a biosimilar version of long-acting semaglutide injection, marketed as Semavic Next, is approved in the Russian Federation for the treatment of obesity
Uses of Tirzepatide Tirzepatide is approved for managing type 2 diabetes
Phentermine has been available since 1959, while semaglutide (the active ingredient in Wegovy and Ozempic) was first approved in 2017
Phase 2 trials - secondary measures Phase 3 results (pending) TRIUMPH and TRANSCEND are the large Phase 3 programmes asking the longer-term safety and outcome questions
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