Pattern 1: The Responder (approximately 60% of switchers) Achieves similar or better weight-loss velocity on Zepbound 7.5 to 10 mg compared to prior Wegovy 2.4 mg Tolerates titration well with transient nausea that resolves within 2 weeks per dose escalation Reaches maintenance dose by week 12 to 16 Reports subjective improvement in appetite suppression ("Zepbound feels stronger") This is the modal response
Early studies suggest that GLP-1 receptor agonists may help reduce these harmful protein accumulations, potentially slowing disease progression
A., & Williams, B
However, if you maintain or continue your weight loss efforts, those facial changes will remain
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Excessive weight gain was the most frequent drug-related adverse event, and increased fat mass was negatively related to change in MHFMS values (p = 0.0409)