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BPC-157 first appeared in the early 1990s, when European researchers wondered why some stomach ulcers healed quickly while others didnt, Flynn McGuire, a physical medicine and rehabilitation resident at the University of Utah who is about to enter a sports medicine fellowship, tells Outside Run

These extracts, which may include licorice root, arbutin, and kojic acid, work synergistically to brighten the skin, fade dark spots, and even out skin tone

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Key benefits: Active, methylated vitamins: L-5-MTHF (folate) and methylcobalamin (B12) for immediate bioavailability

Its brief half-life (about 30 minutes) avoids constant stimulation by imitating physiological GHRH pulses