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Melanotan I (afamelanotide) binds to the melanocortin I receptor (MC1R) to promote melanogenesis, both by proliferation of melanocytes and by regulation of tyrosinase activity

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Treatment typically begins at the lowest available dose and is gradually increased over several weeks based on your tolerance and response to the medication

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Exposure to temperatures above 86F (30C) for extended periods can cause protein denaturation, where the molecular structure unfolds or aggregates, rendering the medication less effective or inactive