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And, unlike conventional radio-chemotherapy, tumors exhibit more complex crosstalk with emerging immunotherapies [16, 17]

Meanwhile, the ratio of GSR to GPX4 at the protein level was decreased in the A2ARi-treated group compared with the control group (Figure 3I), indicating that the GSSG accumulation upon A2ARi treatment is caused likely by an impaired capacity to recycle GSSG back to GSH

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But insufficient glutathione leads to toxin accumulation and increased free radicals which cause diseases and degeneration of the cells