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British Journal of Surgery, 60(8), 646-649
Interestingly, the treatment demonstrated dose-dependent therapeutic effects, with moderate dosages proving more effective than high doses (1,000 mg/kg), possibly due to pharmacodynamic principles, where excessive concentrations saturate biological pathways and diminish therapeutic outcomes (Tyagi et al., 2025
Bot Stud 54:19 Liu X-M, Ren W-J, Lyu H-Y, Chen C-Y, Pan X-H, Bai L-P, Zhang W, Jiang Z-H, Zhu G-Y (2025) Verbenalinosides A and B, two iridoid-phenylethanoid glycoside conjugates from Verbena officinalis and their hepatoprotective activity
10.1038/nature22393 233 WangY.LiC.AliI.LiL.WangG
The FDA has approved mecasermin (Increlex) recombinant native IGF-1 for severe primary IGF-1 deficiency
[Abstract]2022 Dec;9(34):e2203088
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