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Although the adapted program is the optimal solution under current conditions, if the intracellular stress signal persists and the ER function cannot return to normal, the apoptotic program might be initiated (291)

doi: 10.1016/j.bcp.2023.115852 111 RossettiCLAndradeISFonte BoaLFNevesMBFassarellaLBBertassoIMet al

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This is particularly helpful during dose escalation periods when side effects tend to peak

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