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In a 104-week trial, once-weekly subcutaneous semaglutide at 2.4 mg led to a mean change in body weight of -15.2% compared to -2.6% with placebo

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Studies suggest tirzepatide may offer slightly higher weight loss in some individuals (up to about 22.5%), but semaglutide remains a proven, effective option for many patients

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Oral administration is more likely to result in gastrointestinal adverse events, while subcutaneous injection is more likely to lead to endocrine system-related adverse events

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Then, you start taking semaglutide, and suddenly that station is a whole lot quieter

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