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Association and dissociation rate constants were calculated using the kinetics of competitive binding algorithm in GraphPad Prism 43

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It is also worth noting that, consistent with other incretin-based and glucagon co-agonist therapies, small mean increases in heart rate were observed in the trial

(2023) New England Journal of Medicine n=338 Phase 2 trial showing retatrutide produced up to 24.2% body weight loss at 48 weeks, surpassing tirzepatide results