She adds another explanation for why some individuals might seem to observe this association: Weight gain is also linked to the perimenopausal and post-menopausal state, and a GLP-1 is a reasonable treatment for this for those who qualify. What this means is that for some women, the weight loss effects of a GLP-1 and the symptoms of low estrogen may occur at the same time, making it difficult to tell whether the changes are due to the medication, hormonal shifts, or both
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This can happen with or without nausea and vomiting
One pathway that may be underappreciated is the vagus nerve, Kanoski says
To date, research findings have been mixed on whether GLP-1 receptor agonists can help break this cycle
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