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Consistently, our T-maze test also exhibited significant improvement in the performance of 5XFAD, as shown by increase in the number of positive turns (Figure 6F) and reduction of errors (Figure 6G), whereas 5XFAD Ppar-null mice and 5XFAD Ppar-Hippo mice did not display any improvement in T maze analyses (Figure 6, F and G), following Hex treatment, indicating a pivotal role of hippocampal PPAR in Hex-mediated improvement in spatial and contextual in 5XFAD mice

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Based on a willingness-to-pay threshold of GBP 20,000 per QALY gained, oral semaglutide 14 mg remained cost-effective in all analyses with increased incremental costs, even with the liraglutide price reduced by 50% (Fig

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Liraglutide Liraglutide, an analog of human GLP- 1, is given once daily by subcutaneous injection and is resistant to the inactivation by dipeptidyl peptidase- 4 (DPP- 4) [91]

10.1111/j.1440-1681.2010.05351.x 43 Toft-NielsenM