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Cells were incubated with 10 L CCK8 reagent at 37C for 2 hours in the dark

In recent years, different studies on CKD patients and animal models, such as mice, demonstrated that eryptosis, triggered by factors such as uremic toxins, inflammation, oxidative stress, and imbalances in calcium homeostasis, plays a fundamental role in the development and progression of renal anemia

Since GPX4 is critical for neutralizing lipid peroxides, enhancing GPX4 function or ensuring an ample supply of its substrate GSH can significantly lower ferroptosis incidence

World Health Organization (WHO) estimates indicate that among individuals older than 60 years, osteoarthritis prevalence reaches approximately 10% in men and 18% in women

This process occurs when free radicals, highly reactive molecules, wreak havoc on our cells, leading to cellular damage and inflammation