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Rarely reported symptoms associated with excessive B12 intake may include: Skin reactions : Acne-like eruptions or rosacea-type dermatitis have been occasionally reported, particularly with high-dose intramuscular injections Gastrointestinal disturbance : Mild nausea, diarrhoea, or abdominal discomfort, though these are uncommon Headache : Infrequent reports of headaches following parenteral B12 administration Hypersensitivity reactions : In very rare cases, allergic reactions to injectable B12 preparations have been documented It is crucial to note that there is no established link between standard B12 supplementation and serious adverse effects

An untrained injector can provoke mild or moderate to severe side effects with incorrect administration

For the small subset where constipation is severe and unmanageable, stopping the medication is the definitive solution

See our B12 page for more detail

Role of androgens and androgen receptor in control of mitochondrial function