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Fractional CO laser pre-treatment has shown improved absorption of liposome-encapsulated hydrophilic substances, including 5-carboxyfluorescein and ovalbumin, in both pig and murine skin, with a notable increase in permeability linked to the applied laser intensity [257]

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Dietary modifications should emphasise a balanced, Mediterranean-style diet rich in vegetables, fruits, whole grains, lean proteins, and healthy fats whilst limiting processed foods, refined carbohydrates, and saturated fats

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However, our present results showed that an LPA 1/2 agonist had no effect on Bdnf mRNA expression, nor did an LPA 1/3 antagonist on GIN-induced Bdnf expression

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