Durable responses could potentially i) improve tolerability by limiting drug exposure ii) facilitate convenient dosing schedules and increased patient adherence and iii) lead to lower long term costs on our healthcare system/payers
At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days
Int J Mol Sci (2022) 23:1105
The Bottom Line The Medicare GLP-1 Bridge launches in two days
These effects were attributed to the downregulation of critical inflammatory signaling pathways, including nuclear factor-kappa B (NF-B) and mitogen-activated protein kinases (MAPKs), along with inhibition of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression 32,33
Sikiric, P., Seiwerth, S., Rucman, R., Drmic, D., Stupnisek, M., Kokot, A.,