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While the rodent study was single administration, human PD studies suggest that effects dissipate fairly quickly without ongoing doses

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Higher TMAO also positively associated with indicators of central adiposity, including BMI (rho = 0.107, pFDR = 0.09), visceral body fat rating (rho = 0.122, pFDR = 0.09) and waist circumference (rho = 0.119, pFDR = 0.09), after demographics adjustment (Supplementary Fig

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PubMed Alba M, et al