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In addition, GLP-1RA can also directly act on hypothalamic neurons or indirectly act on the AMPK signaling pathway (5355) to promote learning and memory
NRF2 induction supporting breast cancer cell survival is enabled by oxidative stress-induced DPP3-KEAP1 interaction
Outcome measures include neurological severity scoring, rotarod and beam walk performance, histological assessment of lesion volume, and immunohistochemistry for axonal markers and myelin basic protein
In addition, exendin 4 exerted renoprotective effects in animal models through inhibition of nuclear factor-B (NF-B) activity in the kidney, and elevated NF-B activity is known to contribute to the crosstalk between inflammation and oxidative stress 96
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