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Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl (BPTES), a potent orally available GLS1 inhibitor that spares GLS2, shows promising antitumor effects against human lymphoma B cells in vitro and in a xenograft mouse model 42

Go in fast for bleeding, black stools, fever, severe pain, fainting, or fast weight loss

By reducing delays, it may modestly decrease short-term cost increases (if patients can lose weight and reduce related meds faster) and definitely improves provider efficiency

A typical dose ranges from 1,000 to 2,000 mg of combined EPA and DHA daily from fish oil or algae-based supplements

Long-term studies on relapse prevention and combination therapies (e.g., with naltrexone) are also critical

Discrimination index (DI) = BA/E