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Novo Nordisk announced it would advance both formulations to late-stage trials starting in early 2026

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Excess food intake or rapid gastric emptying that exceeds the absorptive capacity of the upper small intestine increases the amount of unabsorbed nutrients in the lumen of the more distally located small intestine, thereby increasing the amount of GLP-1 secretion

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Also, in a real-world cohort of GLP-1 therapy users, the average total body weight loss was ~12.2%, and about 17.8% of patients were classified as non-responders

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