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Guermonprez P , Valladeau J , Zitvogel L , Thry C , Amigorena S

Its an autoimmune disease in which the immune system produces antibodies that attack the thyroid, causing fibrosis or scarring of the thyroid tissue ( Hashimotos disease is associated with a variety of symptoms, including weight gain, fatigue, hair loss, anemia, constipation, cold intolerance, joint pain, dry skin, mood changes, difficulty concentrating, and more ( In addition to medication, diet and lifestyle modification can help reduce thyroid damage and improve symptoms and overall quality of life in people with Hashimotos

It was slow progress with some symptoms getting worse before better

Environmental Pollutants: Exposure to heavy metals, cigarette smoke, and chronic pollution increases the demand for glutathione-driven detoxification

doi:10.1016/j.ijdevneu.2007.08.004 Stefanello FM, Matte C, Pederzolli CD, Kolling J, Mescka CP, Lamers ML, de Assis AM, Perry ML, dos Santos MF, Dutra CS, Wyse ATS (2009) Hypermethioninemia provokes oxidative damage and histological changes in liver of rats

Invest Dermatol 141 (4S), 11191126