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From a regulatory and clinical data perspective, the next steps will be critical

This suggests that it might be more beneficial to check red blood cell folate instead of serum folate in people with Down syndrome

Acknowledgements This work was supported by the National Natural Science Foundation of China (82273092) to LFF and Natural Science Foundation in Zhejiang province (LD22H160003) to XW

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No SAEs were reported, and none of the AEs led to premature treatment discontinuation

For some patients, weight loss was only part of the story