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[4] [5] The three primary subcutaneous injection sites used for comparable licensed therapies (such as semaglutide and tirzepatide, as described in their UK Summary of Product Characteristics) are: Abdomen the area around the stomach, avoiding the area immediately around the navel Front (anterolateral) thigh the outer-front portion of the upper thigh Upper arms the outer area of the upper arm, typically requiring assistance from another person for self-administration The abdomen is generally considered the most accessible and commonly used site, as it offers a relatively large surface area of subcutaneous fat and is straightforward to self-administer

The omission of tirzepatide from the guidelines is likely attributable to the ADAs evidence cutoff occurring prior to the publication of SUMMIT in The New England Journal of Medicine on January 30, 2025

Funding/Support: Funded in part by internal funding (New York State Psychiatric Institute) to Dr Kantrowitz

Retatrutides appetite suppression makes it tempting to skip meals, but this is counterproductive

Cooked vegetables can feel easier than raw salads