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GLP-1 activation can reduce the pathological process of amyloid- plaque aggregation/deposition and tau hyperphosphorylation enhanced by neuroinflammation, thus preventing age-related neurodegenerative changes, such as decline of learning and memory (Li et al., 2012)
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Prolonged receptor stimulation provides reproducible outcomes and allows the study of long-term cumulative effects
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Dog breeds that benefit most from cobalamin supplements are Giant Schnauzers, Chinese Shar-Peis, Border Collies, Beagles, and Australian Shepherds, as they have a genetic predisposition to selective cobalamin malabsorption
By potentially altering how the brain responds to food-related rewards, it is hypothesised that GLP-1 medications might affect other reward-processing systems
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