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self-administration in monkeys (Bergman et al., 1989) and thus may have reinforcing effects by this route in people
The Phase 2 trial ran for 48 weeks, and the Phase 3 TRIUMPH trials extend to 68 weeks and beyond
Additionally, metformin may influence lipid metabolism, smooth muscle contractions of the vascular system, hypercoagulation, platelet hyperactivity, calcium handling within cardiomyocytes and endothelial cell function [34]
doi: 10.3168/jds.2016-12001 34 WiedleGDunonDImhofBA
Their hormonal systems have adapted to lower insulin environments
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