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It depends on the cause of deficiency
Mouse research links high NNMT levels to lower amounts of the sugar transporter GLUT4
Are all types of B12 equally effective
Altered B12 handling and reduced clearance in kidney disease, and both cellular release and reduced clearance in liver disease, can raise B12, so supportive renal or hepatic findings make those causes plausible
Neither approved nor specifically prohibited by Health Canada, it remains available as a research chemical for laboratory investigation
Because no long-term human safety data exists, the conservative clinical approach treats cycling as a prudent default rather than a proven necessity
