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With careful titration, it's the most powerful tool we have for the right patient
In summary, monothiol mechanism (iii), as exemplified for roGFP2(S 2 ) in Fig
The Boc-protected cystine-1,1- 13 C was reacted with two equivalents of glycine tert -butyl ester (OtBu) hydrochloride using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride and 1-hydroxybenzotriazole to produce the N and C-protected dipeptidyl (Boc-Cys-Gly-OtBu) disulfide derivative
Diabetologia (2011) 54:3093100
They form a vicious cycle
Trum et al., 2020)
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