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(November 2021)
doi:10.3389/fnut.2021.614105
and injecting themselves with more of the drug than they should
The rapid inactivation of GLP-1 by the enzyme dipeptidyl peptidase IV (DPP-IV) within minutes prompted the development of GLP-1 analogs with prolonged half-lives, which are now approved for the treatment of T2DM and obesity (semaglutide, 160 h half-life)
Chen, T., & Zhao, X
Some individuals metabolize these medications differently, and factors like diet, hydration, and stress levels can significantly impact results
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