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Its central action in research is competitively blocking NNMT's active site, which does two coupled things: it stops the methylation of nicotinamide (a NAD+ precursor) into 1-methylnicotinamide, and it spares S-adenosylmethionine (SAM), the methyl donor the reaction consumes
CurrPharm Des 26 (25), 29712981
Harmonic restraints of 200 kcal mol 1 2 were applied to the remaining atoms at each stage
