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Accordingly, moderate lean tissue decline observed during GLP-1RA-induced weight loss could be interpreted as a physiological component of body composition change rather than evidence of pathological sarcopenia, unless accompanied by functional deterioration
Psychodynamically, such experiences could activate themes of autonomy versus dependency or idealization versus ambivalenceclassic conflict constellations that may arise whenever external supports influence internal regulatory capacities
The STEP-1 trial (NEJM 2021) demonstrated 14.9% average weight loss with semaglutide 2.4 mg over 68 weeks
Liver biopsy evaluation in MASH drug development: think thrice, act wise
When digestion is delayed, heavier foods can quickly feel uncomfortable, increasing fullness, pressure and nausea
Protein intake becomes especially important on GLP-1 therapy because significant weight loss can include lean muscle mass if protein intake is inadequate
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