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93, S89S96

Sodium oxybate is a sodium salt of gamma-hydroxybutyrate (a short-chain fatty acid), which is a neurotransmitter synthesized from its precursor gamma amino butyric acid (GABA)

Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway

According to the Appendix, SOLSTICE met its primary endpoint, demonstrating clinically meaningful HbA1c reductions over 26 weeks in adults with type 2 diabetes. In obesity and overweight, the Phase IIb VISTA trial (NCT06579092) assessed multiple oral doses of elecoglipron versus placebo, using coprimary endpoints of percentage change in body weight and the proportion of participants achieving at least 5% weight loss at 26 weeks

Maitra 1996

Scand J Gastroenterol 57(7):783791