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Additionally, the development of oral GLP-1 therapeutics opens up avenues for addressing comorbidities associated with obesity and type 2 diabetes, such as cardiovascular diseases and fatty liver disease

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GEP44-mediated increases in glucose transport also correlated with its stimulation of lactate production and thus a downstream impact on muscle metabolism

412 Despite these above factors, evidences persist that endothelial dysfunction, oxidative stress, and vitamin D deficiency are important in the glucose intolerance pathogenesis and IR in patients with CKD