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Most cosmetic actives have a 10-fold to 100-fold therapeutic window

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But what are its effects in the body

Hydroxocobalamin, the form most commonly used in the UK, may cause: Injection site reactions (pain, redness, or swelling) Temporary reddish discolouration of urine Rarely, hypersensitivity reactions Very rarely, hypokalaemia in severely deficient patients when treatment is initiated (potassium levels should be monitored in severe deficiency) B12 injections are considered very safe, with no upper tolerable limit established, as excess B12 is excreted in urine

These include traction alopecia, androgenic alopecia, and hyperthyroidism, among others

Carmona, D