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Moreover, AMPK exhibited a comparable half-life in shCtrl and shGDH1 cells in a cycloheximide (CHX) chase assay (Extended Data Fig
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Figure 5 ALC reduced cholesterol synthesis by decreasing SREBP2 levels in Huh-7 hepatocytes To elucidate the cellular mechanisms underlying ALCs cholesterol-lowering effects, ALC reduced the plasma TC in mice and decreased the hepatic SREBP2 and HMGCR levels
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The impact of folate-related variants may depend on levels of riboflavin, choline, betaine, and vitamin B12especially during periods of physiological stress
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