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in the abdomen)
SURMOUNT-1: la referencia en obesidad sin diabetes SURMOUNT-1 (Jastreboff et al., NEJM 2022) incluy 2.539 participantes con obesidad (IMC medio 38 kg/m) o sobrepeso con al menos una complicacin relacionada con el peso, sin diabetes tipo 2
Research has identified specific genetic polymorphismsincluding GIPR rs1800437that correlate with differential medication response
Both contain semaglutide as the active ingredient and work via the same GLP-1 receptor mechanism
They performed experiments on human hepatic L02 cells treated with CdCl2 and found that Drp1 and retinoblastoma (RB) protein levels were increased and translocated to mitochondria in CdCl 2 -treated cells
The choice depends on baseline weight, metabolic history, and genetic predisposition to GLP-1 versus GIP pathway sensitivity
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